Senior Scientist/Principal Scientist, Pharmacology

About BBOT:

BBOT is a clinical-stage biopharmaceutical company advancing a next generation pipeline of novel small molecule therapeutics targeting RAS and PI3K malignancies. Initially formed as a subsidiary of BridgeBio Services, BBOT completed a $200M private financing with external investors in 2024 with the goal of improving outcomes for patients with cancers driven by the two most prevalent oncogenes in human tumors. For more information visit:  BBOTx.com 

Who You Are:

The BBOT team is hiring an exceptional and motivated Senior Scientist/Principal Scientist to contribute to collaborative teams focused on the discovery and development of novel targeted small molecule oncology therapeutics. The successful candidate will be a results-driven scientist with extensive in vivo pharmacology experience and a keen understanding of the small molecule oncology drug discovery process. We are looking for a talented and enthusiastic individual who thrives in a collaborative, fast-paced, and growing environment to join our team.

Responsibilities:

• Drive and implement the pharmacology strategy for small molecule therapeutics for oncology indications through lead optimization, development candidate selection, IND-enabling, and clinical development stages 
• Serve as the pharmacology functional team leader for one or more programs and collaborate with cross-functional program teams and leaders to support molecule advancement 
• Lead in vivo (model development, tolerability, PK/PD, and efficacy) and ex vivo (target and mechanism engagement) studies to assess the inhibition or activation of oncology targets with novel small molecule therapeutics
• Manage and provide strategic and technical leadership to a team of research associates 
• Write reports and regulatory documents 
• Lead academic collaborations with academic researchers and KOLs 
• Manage CROs to deliver high quality data in a timely manner 

Education, Experience & Skills Requirements:

• A highly motivated, committed individual with good organizational skills and a demonstrated commitment to quality, attention to detail, and team player mentality
• Ph.D. in a biology-related discipline with postdoctoral fellowship and at least 3 years of industry experience is required 
• Accomplished oncology scientist as evidenced by publication record 
• Broad experience with in vivo CDX, PDX, and syngeneic models 
• Experience managing scientist and research associate level personnel and demonstrated ability to effectively train, manage, and mentor associates on proper in vivo protocols and procedures 
• Experience managing diverse and multiple CROs
• Strong written and oral communication skills
• Experience writing pharmacology section of IND a plus 

Compensation:

BBOT considers a variety of factors when determining base compensation, including experience, skills, education, qualifications, and geographic location. Actual compensation will vary, and it is not typical to be hired at or near the top of the range for the role.

Base compensation is part of a robust total rewards offering at BBOT. Additional total rewards elements include annual bonus, stock-based long-term incentives, medical, dental, and vision benefits, retirement, wellness stipend, and flexible time off.